Die Prophylaxe von rezidivierenden HWI mit kontinuierlicher Gabe von Nitrofurantoin oder Cephalexin für einen Zeitraum von 6–12 Monaten scheint sehr effektiv zu sein.
In manchen Studien wurde ein positiver Effekt für Preiselbeer-Produkte nachgewiesen. Aufgrund der fehlenden Datenlage gibt es hierfür aber noch keine gute Evidenz, und es kann keine sichere Empfehlung hinsichtlich ihres Gebrauchs erfolgen.
Besteht der Hinweis auf einen komplizierten HWI (insbesondere Hämaturie nach Infektsanierung) sollten die Patienten zur weiteren Abklärung zu einem Facharzt für Urologie zugewiesen werden.
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