ATM Kinase as a Critical Regulator of Melanoma Invasion and Metastasis

This study established a high-throughput screening platform (Invasion-Block) and a customizable image analysis pipeline (S-MARVEL) for the identification of potential anti-cancer drugs and the downstream quantification of drug actions, respectively.

Coupling Invasion-Block and S-MARVEL, we screened 3,840 FDA-approved compounds and found kinase inhibitors to be the best drug class for inhibiting melanoma invasion.

The hits generated were subsequently validated in vitro and in vivo leading to the identification of ATM kinase as a novel modulator of melanoma invasion and metastasis.